Frontal and occipital brain glutathione levels are unchanged in autistic adults
GSH levels as measured using 1H-MRS are unaltered in the DMPFC and mOCC regions of autistic adults, suggesting that oxidative stress in these cortical regions is not a marked neurobiological signature of ASD.
Authors
- Alison Leonard (ORCID: https://orcid.org/0000-0002-8832-8275)
- Claire L. Ellis (ORCID: https://orcid.org/0000-0002-1064-2395)
- Łukasz Kowalewski (ORCID: https://orcid.org/0000-0002-2259-5645)
- Diana-Georgina Rotaru
- Nichol M. L. Wong (ORCID: https://orcid.org/0000-0003-0050-7736)
- Hester Velthuis (ORCID: https://orcid.org/0000-0001-9219-3687)
- Charlotte M. Pretzsch (ORCID: https://orcid.org/0000-0002-2761-6628)
- Glynis Ivin
- Richard A.E. Edden (ORCID: https://orcid.org/0000-0002-0671-7374)
- Declan Murphy (ORCID: https://orcid.org/0000-0002-6664-7451)
- Gráinne McAlonan (ORCID: https://orcid.org/0000-0002-4466-2343)
- Mihail Dimitrov (ORCID: https://orcid.org/0000-0002-0760-5905)
- Eileen Daly (ORCID: https://orcid.org/0000-0003-3625-3467)
- Andreia C. Pereira (ORCID: https://orcid.org/0000-0003-4418-2638)
- David J. Lythgoe (ORCID: https://orcid.org/0000-0002-5078-9025)
- Francesca M. Ponteduro (ORCID: https://orcid.org/0000-0002-1244-3090)
Institutions
- Kennedy Krieger Institute (US)
- Royal College of Surgeons in Ireland (IE)
- Johns Hopkins University (US)
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- Education University of Hong Kong (HK)
- University of Coimbra (PT)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1371/journal.pone.0308792
- Citations
- 3
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 1.03
Funders
- Brain and Behavior Research Foundation
- Autistica
- Sackler Institute for Translational Neurodevelopment, King's College London
- Medical Research Council