Utility of SATB2 and MOC-31 Immunostains to Distinguish Between Poorly Differentiated Rectal Adenocarcinoma and Anal Squamous Cell Carcinoma
Unlike squamous mucosa of the head and neck, and esophagus, SCC of the anus does not frequently stain positively for SATB2. These data suggest that SATB2 is a reliable marker in distinguishing rectal PDA from anorectal nonkeratinizing SCC, whereas MOC-31 is commonly positive in SCC of the anus. It is also important to note that equivocal SATB2 staining may be seen in SCC.
Authors
- Jerome Cheng (ORCID: https://orcid.org/0000-0001-8949-7006)
- Jiayun M. Fang (ORCID: https://orcid.org/0000-0001-9517-297X)
- Laura W. Lamps (ORCID: https://orcid.org/0000-0002-6847-5104)
- Naziheh Assarzadegan (ORCID: https://orcid.org/0000-0002-3368-3202)
Institutions
- University of Michigan (US)
- University of Florida (US)
- VA Ann Arbor Healthcare System (US)
Publication Details
- Journal
- Applied immunohistochemistry & molecular morphology
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1097/pai.0000000000001218
- Primary Topic
- Colorectal and Anal Carcinomas
- Type
- article
- Field-Weighted Citation Impact
- 0.00