Population Pharmacokinetics and Target Attainment of Allopurinol and Oxypurinol Before, During, and After Cardiac Surgery with Cardiopulmonary Bypass in Neonates with Critical Congenital Heart Disease

The minimal target concentration of allopurinol was not achieved at every predefined time interval in the CRUCIAL trial; however, the dosing strategy used was deemed adequate, since it yielded concentrations well exceeding the IC90<sub>XO</sub>. The decreased CL of both compounds during CPB suggests influence of the hypothermia, hemofiltration, and the potential sequestration of allopurinol in the circuit. The reduced CL of oxypurinol after CPB is likely attributable to impaired kidney function.

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Publication Details

Journal
Clinical Pharmacokinetics
Published
2024-08-01
DOI
https://doi.org/10.1007/s40262-024-01401-3
Primary Topic
Mechanical Circulatory Support Devices
Type
article
Field-Weighted Citation Impact
0.00

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article

Population Pharmacokinetics and Target Attainment of Allopurinol and Oxypurinol Before, During, and After Cardiac Surgery with Cardiopulmonary Bypass in Neonates with Critical Congenital Heart Disease

Joppe Nijman, Alwin D. R. Huitema, Maaike Nijman, Manon J.N.L. Benders et al.
Clinical Pharmacokinetics
Mechanical Circulatory Support Devices
article

Population Pharmacokinetics and Target Attainment of Allopurinol and Oxypurinol Before, During, and After Cardiac Surgery with Cardiopulmonary Bypass in Neonates with Critical Congenital Heart Disease

Joppe Nijman, Alwin D. R. Huitema, Maaike Nijman, Manon J.N.L. Benders, Thomas P. C. Dorlo, Erik Koomen, Nicolaas J. G. Jansen, Raymond Stegeman, Wan‐Yu Chu, Johannes M. P. J. Breur, Kim van Loon, Karel Allegaert
article en

Abstract

The minimal target concentration of allopurinol was not achieved at every predefined time interval in the CRUCIAL trial; however, the dosing strategy used was deemed adequate, since it yielded concentrations well exceeding the IC90<sub>XO</sub>. The decreased CL of both compounds during CPB suggests influence of the hypothermia, hemofiltration, and the potential sequestration of allopurinol in the circuit. The reduced CL of oxypurinol after CPB is likely attributable to impaired kidney function.

Clinical PharmacokineticsVol. 63(8)
Uppsala University (SE), University of Groningen (NL), University of Applied Sciences Utrecht (NL), Utrecht University (NL), Erasmus MC (NL), The Netherlands Cancer Institute (NL), University Medical Center Utrecht (NL), Oncode Institute (NL), Princess Máxima Center (NL), Wilhelmina Children's Hospital (NL), KU Leuven (BE)
ZonMw
Good health and well-being
Openalex Percentile: Top 88%
Mechanical Circulatory Support Devices
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