Clinical, Pathologic, and Dosimetric Predictors of Head and Neck Lymphedema Following Definitive or Adjuvant Radiation Therapy for Head and Neck Cancer
HNL following HNC treatment is common. For both external and internal lymphedema, nodal disease burden at diagnosis predicts increased risk. For external lymphedema, increasing extent of lymph node dissection prior to adjuvant therapy increases risk. The contralateral level VII lymph node region is also predictive of external lymphedema when radiation dose to V30 is ≥50%, meriting investigation. For internal lymphedema, we confirm that increasing radiation dose to the larynx is the most significant dosimetric predictor of mucosal edema when larynx V45 is ≥50%.
Authors
- Bharat B. Mittal (ORCID: https://orcid.org/0000-0002-6541-8753)
- Clayton E. Lyons (ORCID: https://orcid.org/0009-0001-4066-6830)
- Michelle Gentile
- Suvidya Lakshmi Pachigolla
- Indra J. Das (ORCID: https://orcid.org/0000-0003-4094-0892)
- Kevin Rogacki (ORCID: https://orcid.org/0000-0003-2666-705X)
- Mohamed E. Abazeed (ORCID: https://orcid.org/0000-0002-6614-4440)
- P. T. Teo (ORCID: https://orcid.org/0000-0003-1889-966X)
- Mahesh Gopalakrishnan (ORCID: https://orcid.org/0009-0001-9140-0573)
Institutions
- Illinois College (US)
- University of Illinois Chicago (US)
- Northwestern Memorial Hospital (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- University of Pennsylvania (US)
Publication Details
- Journal
- Advances in Radiation Oncology
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1016/j.adro.2024.101545
- Citations
- 5
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.41