Amantamide C, an Antitrypanosomal Linear Lipopeptide from a Marine <i>Okeania</i> sp. Cyanobacterium
Amantamides are lipopeptides that act as selective CXC chemokine receptor 7 agonists and modulate spontaneous calcium oscillations in primary cultured neocortical neurons. We isolated a new analog of amantamides, amantamide C, from marine <i>Okeania</i> sp. cyanobacterium collected in Japan and established its structure based on NMR and MS/MS analyses, and degradation reactions. In addition, we evaluated the biological activity of amantamide C and revealed novel biological features of amantamide-type compounds.
Authors
- Natsumi Watanabe (ORCID: https://orcid.org/0009-0001-3331-5354)
- Ghulam Jeelani (ORCID: https://orcid.org/0000-0003-0816-9831)
- Tomoyoshi Nozaki (ORCID: https://orcid.org/0000-0003-1354-5133)
- Arihiro Iwasaki (ORCID: https://orcid.org/0000-0002-3775-5066)
Institutions
- The University of Tokyo (JP)
- Chuo University (JP)
Publication Details
- Journal
- ACS Omega
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1021/acsomega.4c05909
- Citations
- 3
- Primary Topic
- Marine Sponges and Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Naito Foundation
- Keio University
- Japan Society for the Promotion of Science