Impact of proton pump inhibitor use on clinical outcomes in East Asian patients receiving clopidogrel following drug-eluting stent implantation

In post-PCI patients receiving clopidogrel-based DAPT, PPI use was not linked to an increased risk of adverse cardiac and cerebrovascular events, but there was a small but significant increase in on-treatment PRU. Future research using a more individualized approach would further elucidate these interactions and guide evidence-based clinical practices.

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Publication Details

Journal
BMC Medicine
Published
2024-08-15
DOI
https://doi.org/10.1186/s12916-024-03549-y
Citations
1
Primary Topic
Antiplatelet Therapy and Cardiovascular Diseases
Type
article
Field-Weighted Citation Impact
0.40

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article

Impact of proton pump inhibitor use on clinical outcomes in East Asian patients receiving clopidogrel following drug-eluting stent implantation

Byeong‐Keuk Kim, Ae‐Young Her, Ju Hyeon Kim, Kiyuk Chang et al.
1 citations
BMC Medicine
Antiplatelet Therapy and Cardiovascular Diseases
0.40
article

Impact of proton pump inhibitor use on clinical outcomes in East Asian patients receiving clopidogrel following drug-eluting stent implantation

Byeong‐Keuk Kim, Ae‐Young Her, Ju Hyeon Kim, Kiyuk Chang, Sang Yeub Lee, Jae Hyoung Park, Cheol Woong Yu, Jung‐Won Suh, Jung‐Joon Cha, Hyung Joon Joo, Hyo‐Soo Kim, Young Bin Song, Yongwhi Park, Young‐Hoon Jeong, Sung Gyun Ahn, Soon Jun Hong, Tae Hoon Ahn, Jung Rae Cho, Eun‐Seok Shin, Moo Hyun Kim, Subin Lim, Do-Sun Lim
article en
1 citations

Abstract

In post-PCI patients receiving clopidogrel-based DAPT, PPI use was not linked to an increased risk of adverse cardiac and cerebrovascular events, but there was a small but significant increase in on-treatment PRU. Future research using a more individualized approach would further elucidate these interactions and guide evidence-based clinical practices.

BMC MedicineVol. 22(1)
Ulsan College (KR), Hallym University (KR), Kangwon National University (KR), Changwon National University (KR), Gyeongsang National University (KR), Yonsei University (KR), Severance Hospital (KR), Korea University Medical Center (KR), Dong-A University Hospital (KR), Samsung Medical Center (KR), Seoul National University Hospital (KR), Seoul National University Bundang Hospital (KR), University of Ulsan (KR), Hallym University Kangnam Sacred Heart Hospital (KR), Wonju Severance Christian Hospital (KR), Ulsan University Hospital (KR), Chung-Ang University Hospital (KR), Korea University (JP), Sungkyunkwan University (KR), Catholic University of Korea (KR)
Korea University
Good health and well-being
Openalex Percentile: Top 34%
Antiplatelet Therapy and Cardiovascular Diseases
0.40
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