Association of body shape phenotypes and body fat distribution indexes with inflammatory biomarkers in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank
Specific indexes of body size and body fat distribution showed differential associations with inflammation in adults. Notably, our results suggest that in women, height may mitigate the impact of a higher WC and HC on inflammation. This suggests that subtypes of adiposity exhibit substantial variation in their inflammatory potential, which may have implications for inflammation-related chronic diseases.
Authors
- Esther M. González‐Gil (ORCID: https://orcid.org/0000-0003-2005-8229)
- Anja M. Sedlmeier (ORCID: https://orcid.org/0000-0002-7564-3065)
- Pilar Amiano Etxezarreta
- Carine Biessy (ORCID: https://orcid.org/0000-0003-3950-0929)
- Laia Peruchet‐Noray (ORCID: https://orcid.org/0000-0001-8742-8920)
- Sofia Christakoudi (ORCID: https://orcid.org/0000-0001-9219-4436)
- Hansjörg Baurecht (ORCID: https://orcid.org/0000-0002-9265-5594)
- Erand Llanaj (ORCID: https://orcid.org/0000-0003-4300-0433)
- Sabina Rinaldi (ORCID: https://orcid.org/0000-0002-6846-1204)
- Nuno R. Zilhäo (ORCID: https://orcid.org/0000-0002-4648-4288)
- W. M. Monique Verschuren (ORCID: https://orcid.org/0000-0003-2134-4227)
- Matthias Bernd Schulze (ORCID: https://orcid.org/0000-0002-0830-5277)
- Fulvio Ricceri (ORCID: https://orcid.org/0000-0001-8749-9737)
- Yahya Mahamat‐Saleh (ORCID: https://orcid.org/0000-0002-5892-8886)
- Vittorio Simeon (ORCID: https://orcid.org/0000-0003-2387-4125)
- Sabina Sieri (ORCID: https://orcid.org/0000-0001-5201-172X)
- Giovanna Masala (ORCID: https://orcid.org/0000-0002-5758-9069)
- Vivian Viallon (ORCID: https://orcid.org/0000-0002-9799-4421)
- Marcela Guevara (ORCID: https://orcid.org/0000-0001-9242-6364)
- Dagfinn Aune (ORCID: https://orcid.org/0000-0002-4533-1722)
- Laure Dossus (ORCID: https://orcid.org/0000-0003-2716-5748)
- Rola Jaafar (ORCID: https://orcid.org/0000-0001-9477-7678)
- Marc J. Gunter (ORCID: https://orcid.org/0000-0001-5472-6761)
- Carlota Castro‐Espín (ORCID: https://orcid.org/0000-0001-9050-7590)
- Anne‐Sophie Navionis (ORCID: https://orcid.org/0009-0002-9854-1114)
- Sandra M. Colorado‐Yohar (ORCID: https://orcid.org/0000-0002-6700-0780)
- Heinz Freisling (ORCID: https://orcid.org/0000-0001-8648-4998)
- Anja Olsen (ORCID: https://orcid.org/0000-0003-4788-503X)
- Dafina Petrova (ORCID: https://orcid.org/0000-0002-0346-6776)
- Christina C. Dahm (ORCID: https://orcid.org/0000-0003-0481-2893)
- Anne Marie Tjønneland (ORCID: https://orcid.org/0000-0003-4385-2097)
- Jolanda M.A. Boer (ORCID: https://orcid.org/0000-0002-9714-4304)
- Tim Key
- Alicia K. Heath
Institutions
- University of Copenhagen (DK)
- University of Potsdam (DE)
- OsloMet – Oslo Metropolitan University (NO)
- University of Campania "Luigi Vanvitelli" (IT)
- Aarhus University (DK)
- Basque Government (ES)
- Bellvitge University Hospital (ES)
- University Medical Center Utrecht (NL)
- University Hospital Regensburg (DE)
- Universidad de Antioquia (CO)
- University of Oxford (GB)
- Instituto de Salud Pública de Navarra (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Ministry of Health (ES)
- Biogipuzkoa Health Research Institute (ES)
- National Institute for Public Health and the Environment (NL)
- Institut Català d'Oncologia (ES)
- Navarre Institute of Health Research (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Central Denmark Region (DK)
- Cancer Registry of Norway (NO)
- Danish Cancer Society (DK)
- Piedmont Reference Center for Epidemiology and Cancer Prevention (IT)
- Deutsches Diabetes-Zentrum e.V. (DE)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- German Center for Diabetes Research (DE)
- German Institute of Human Nutrition (DE)
- Centre international de recherche sur le cancer (FR)
- Heinrich Heine University Düsseldorf (DE)
- Imperial College London (GB)
- University of Turin (IT)
- University of Regensburg (DE)
- Andalusian School of Public Health (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1186/s12916-024-03544-3
- Citations
- 14
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 4.57
Funders
- Deutsches Krebsforschungszentrum
- Wellcome Trust
- Cancer Research UK
- National Institute for Health and Care Research
- British Heart Foundation
- Deutsche Forschungsgemeinschaft
- Institut National de la Santé et de la Recherche Médicale
- Bundesministerium für Bildung und Forschung
- Ligue Contre le Cancer
- Northwest Regional Development Agency
- Vetenskapsrådet
- Deutsche Krebshilfe
- Institut National Du Cancer
- Institut Gustave-Roussy
- Mutuelle Générale de l'Education Nationale
- Medical Research Council
- World Cancer Research Fund
- Instituto de Salud Carlos III
- NIHR Imperial Biomedical Research Centre
- National Cancer Institute