Polygenic risk scores for nicotine use and family history of smoking are associated with smoking behaviour
These results show the potential utility of molecular genetic data for research investigating smoking prevention. The fact that PRS explains more variance than family history highlights progress from formal to molecular genetics; the partial overlap and increased predictive value when using both suggests the importance of combining these approaches.
Authors
- Michael Nothnagel (ORCID: https://orcid.org/0000-0001-8305-7114)
- Josef Frank (ORCID: https://orcid.org/0000-0003-4867-9465)
- Rainer Spanagel (ORCID: https://orcid.org/0000-0003-2151-4521)
- Norman Zacharias (ORCID: https://orcid.org/0000-0001-5794-5716)
- Lea Sirignano (ORCID: https://orcid.org/0000-0002-7989-5833)
- Michael Wagner (ORCID: https://orcid.org/0000-0003-2589-6440)
- Bernd Lenz (ORCID: https://orcid.org/0000-0001-6086-0924)
- Henrik Walter (ORCID: https://orcid.org/0000-0002-9403-6121)
- Stephanie H. Witt (ORCID: https://orcid.org/0000-0002-1571-1468)
- Falk Kiefer (ORCID: https://orcid.org/0000-0001-7213-0398)
- Jerome C. Foo (ORCID: https://orcid.org/0000-0003-1067-5725)
- Lea Zillich (ORCID: https://orcid.org/0000-0001-7457-374X)
- Peter Nürnberg (ORCID: https://orcid.org/0000-0002-7228-428X)
- Maja P. Völker (ORCID: https://orcid.org/0000-0002-6842-9386)
- Fabian Streit (ORCID: https://orcid.org/0000-0003-1080-4339)
- Georg Winterer (ORCID: https://orcid.org/0000-0002-3610-5029)
- Marcella Rietschel (ORCID: https://orcid.org/0000-0002-5236-6149)
- Markus M. Nöthen (ORCID: https://orcid.org/0000-0002-8770-2464)
- Thomas F. Wienker
Institutions
- University of Cologne (DE)
- Heidelberg University (DE)
- University Hospital Bonn (DE)
- University Hospital Heidelberg (DE)
- Humboldt-Universität zu Berlin (DE)
- Central Institute of Mental Health (DE)
- Max Planck Institute for Molecular Genetics (DE)
- University Hospital Cologne (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Drug and Alcohol Dependence
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1016/j.drugalcdep.2024.112415
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung