Axially Chiral Phenanthroline Ligand-Enabled Copper-Catalyzed Enantioselective Arylation of Azonaphthalenes with Arylboronic Acids
Abstract An axially chiral phenanthroline ligand bearing two BINOL units was found to be capable of promoting the copper-catalyzed enantioselective arylation of 2-azonaphthalenes with arylboronic acids. This atroposelective Michael-type addition affords a range of enantioenriched axially chiral biaryl compounds in synthetically useful yields with enantiomeric ratios of up to 91.5:8.5.
Authors
- Zhipeng Zhang (ORCID: https://orcid.org/0000-0003-2767-0904)
- Shouyi Cen (ORCID: https://orcid.org/0000-0002-9786-6067)
- Ruiyu Wang (ORCID: https://orcid.org/0000-0003-1608-140X)
Institutions
- East China University of Science and Technology (CN)
Publication Details
- Journal
- Synlett
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1055/a-2388-9630
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities