Dendritic, Water‐Soluble, and Nonaggregated Axially Substituted Silicon Phthalocyanine as Potential Endometrial Anticancer Agent
ABSTRACT In this work, dendritic, water‐soluble, and nonaggregated axially substituted silicon phthalocyanines ( EA‐TD‐Si and EA‐TD‐SiQ ) were synthesized and characterized. Then, the supercoiled pBR322 plasmid DNA damage properties of EA‐TD‐Si and EA‐TD‐SiQ were examined using agarose gel electrophoresis without light irradiation. In addition, the cytotoxicity and phototoxicity of EA‐TD‐Si and EA‐TD‐SiQ on human endometrium adenocarcinoma (HEC‐1B) cells were investigated using an MTT assay. The results indicated that EA‐TD‐SiQ had high photodamage properties via singlet oxygen depending on the light dose, while EA‐TD‐Si did not show any DNA damage without light. In addition, EA‐TD‐SiQ had higher phototoxic effects than EA‐TD‐Si on HEC‐1B cells according to the MTT assay. These results revealed the potential of EA‐TD‐SiQ to be used as a PDT agent in endometrial cancer.
Authors
- Burak Barut (ORCID: https://orcid.org/0000-0002-7441-8771)
- Gökçe Seyhan (ORCID: https://orcid.org/0000-0002-8553-9093)
- Rengin Reis (ORCID: https://orcid.org/0000-0002-3484-2201)
- Zekeriya Bıyıklıoğlu (ORCID: https://orcid.org/0000-0001-5138-214X)
- Turgut Keleş (ORCID: https://orcid.org/0000-0002-1911-8020)
- Kübra Kolci (ORCID: https://orcid.org/0000-0003-4228-6564)
Institutions
- Yeditepe University (TR)
- Recep Tayyip Erdoğan University (TR)
- Karadeniz Technical University (TR)
- Kent Hastanesi (TR)
- Acıbadem Adana Hospital (TR)
Publication Details
- Journal
- Applied Organometallic Chemistry
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1002/aoc.7699
- Primary Topic
- Porphyrin and Phthalocyanine Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00