Agrimonia coreana Extract Exerts Its Therapeutic Effect through CRAC Channel Inhibition for Atopic Dermatitis Treatment
Atopic dermatitis (AD) is a common allergic inflammatory skin condition marked by severe itching, skin lichenification, and chronic inflammation. AD results from a complex immune response, primarily driven by T lymphocytes and environmental triggers, leading to a disrupted epidermal barrier function. Traditional treatments, such as topical corticosteroids, have limitations due to long-term side effects, highlighting the need for safer alternatives. Here, we aimed to show that <i>Agrimonia coreana</i> extract (AC<sub>ext</sub>) can be used in treating AD-related dermatologic symptoms. AC<sub>ext</sub> could inhibit CRAC (Calcium Release-Activated Calcium) channel activity, reducing Orai1/CRAC currents and decreasing intracellular calcium signaling. This inhibition was further confirmed by the reduced IL-2 levels and T cell proliferation upon AC<sub>ext</sub> treatment. In a mouse model of AD, AC<sub>ext</sub> significantly ameliorates symptoms, improves histological parameters, and enhances skin barrier function, demonstrating its potential for treating AD.
Authors
- Seong Woo Choi (ORCID: https://orcid.org/0000-0002-7906-495X)
- Joo‐Hyun Nam (ORCID: https://orcid.org/0000-0001-8300-6974)
- Yu Ran Nam (ORCID: https://orcid.org/0000-0001-7816-2585)
- Hyun Jong Kim (ORCID: https://orcid.org/0000-0002-6130-7028)
- Su Jin Park (ORCID: https://orcid.org/0000-0002-6025-3160)
- Jintae Kim (ORCID: https://orcid.org/0009-0006-9817-6726)
- Ji Min Lee (ORCID: https://orcid.org/0000-0003-4699-551X)
- Woo Kyung Kim (ORCID: https://orcid.org/0000-0003-0359-3967)
Institutions
- Dongguk University (KR)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2024-08-15
- DOI
- https://doi.org/10.3390/ijms25168894
- Citations
- 1
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.53