Microwave Promoted Tandem Reaction of Free Primary Arylamines with Diazo Compounds Under Metal‐Free Condition in Water: Clean Synthesis of 2,2‐Disubstituted 3‐Oxindoles
Herein, a microwave promoted tandem reaction of free primary arylamines with diazo compounds in water for clean synthesis of 2,2-disubstituted 3-oxindoles is present. Water plays important roles in the whole cascade process: O-H insertion to diazo, air oxidation, ortho C-H functionalization, cyclization and 1,2-ester migration. In particular, water plays a mediation role in the site selective ortho-C-H addition.
Authors
- Yangjie Wu (ORCID: https://orcid.org/0000-0002-0134-0870)
- Xiuling Cui (ORCID: https://orcid.org/0000-0001-5759-766X)
- Chao Pi (ORCID: https://orcid.org/0000-0002-3404-1543)
- Yong Wang (ORCID: https://orcid.org/0000-0002-8646-613X)
Institutions
- Zhengzhou University (CN)
- Henan University of Engineering (CN)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1002/chem.202402974
- Citations
- 1
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.25