<scp>MHCI</scp> trafficking signal‐based <scp>mRNA</scp> vaccines strengthening immune protection against <scp>RNA</scp> viruses
The major histocompatibility complex class I (MHCI) trafficking signal (MITD) plays a pivotal role in enhancing the efficacy of mRNA vaccines. However, there was a lack of research investigating its efficacy in enhancing immune responses to RNA virus infections. Here, we have developed an innovative strategy for the formulation of mRNA vaccines. This approach involved the integration of MITD into the mRNA sequence encoding the virus antigen. Mechanistically, MITD-based mRNA vaccines can strengthen immune protection by mimicking the dynamic trafficking properties of MHCI molecule and thus expand the memory specific B and T cells. The model MITD-based mRNA vaccines encoding binding receptor-binding domain (RBD) of SARS-CoV-2 were indeed found to achieve protective duration, optimal storage stability, broad efficacy, and high safety.
Authors
- Songhui Zhai (ORCID: https://orcid.org/0009-0007-5971-9123)
- Zhongwei Zhang
- Hai Huang (ORCID: https://orcid.org/0000-0003-2123-6533)
- Kepan Chen (ORCID: https://orcid.org/0000-0002-0610-2556)
- Xin Jiang (ORCID: https://orcid.org/0000-0002-7288-8278)
- Xingchen Peng (ORCID: https://orcid.org/0000-0001-7042-718X)
- Yupei Zhang (ORCID: https://orcid.org/0000-0001-8348-0545)
- Shugang Qin (ORCID: https://orcid.org/0000-0002-5771-6785)
- Yaoyao Luo (ORCID: https://orcid.org/0009-0007-2708-4637)
- Yuting Chen (ORCID: https://orcid.org/0000-0003-4579-6498)
- Guo-Hong Li (ORCID: https://orcid.org/0000-0003-4811-8430)
- Hao Li (ORCID: https://orcid.org/0000-0003-0507-0297)
- Xi He (ORCID: https://orcid.org/0000-0003-3902-028X)
- Xiangrong Song
- Meiwan Chen (ORCID: https://orcid.org/0000-0002-8642-5979)
- Zhiying Huang (ORCID: https://orcid.org/0009-0006-5088-8249)
- Xing Lan
Institutions
- University of Macau (MO)
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
Publication Details
- Journal
- Bioengineering & Translational Medicine
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1002/btm2.10709
- Citations
- 2
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Sichuan University
- National Key Research and Development Program of China
- West China Hospital, Sichuan University