<i>Eugenia Pohliana</i> Leaves Essential Oil Inhibits Fungal Virulence and Restores Antibiotic Efficacy in Multidrug‐Resistant Bacterial Strains
This study aims to investigate the essential oil from leaves of Eugenia pohliana (EOEP) in regard to its chemical composition, antimicrobial and drug-enhancing activity, as well as the reduction of fungal virulence capacity. Chemical characterization using GC-MS showed as major components the sesquiterpenes δ-cadinene, Epi-α-Muurolol, and bicyclogermacrene. The results of antibacterial tests indicated that Staphylococcus aureus was more sensitive to EOEP, that also enhanced the efficacy of gentamicin, erythromycin, and norfloxacin. EOEP exhibited antifungal properties against Candida albicans, in addition to potentiating the effectiveness of fluconazole against Candida tropicalis. It showed anti-virulence effects in all fungal strains. These findings underscore E. pohliana as a potential candidate for the prospection of novel therapeutic agents to treat infectious diseases caused by resistant microbes.
Authors
- Maria Flaviana Bezerra Morais‐Braga (ORCID: https://orcid.org/0000-0002-5898-1257)
- José Walber Gonçalves Castro (ORCID: https://orcid.org/0000-0002-5791-5880)
- Lilian Cortez Sombra Vandesmet (ORCID: https://orcid.org/0000-0003-3342-4814)
- Marcos Aurélio Figueirêdo dos Santos (ORCID: https://orcid.org/0000-0002-3409-5242)
- Viviane Bezerra da Silva (ORCID: https://orcid.org/0000-0003-0581-2609)
- Raimundo Luíz Silva Pereira (ORCID: https://orcid.org/0000-0001-8205-7120)
- Saulo Almeida de Menezes (ORCID: https://orcid.org/0000-0001-6657-585X)
- Clara Mariana Gonçalves Lima (ORCID: https://orcid.org/0000-0002-3150-9139)
- Maria Tereza dos Santos Correia (ORCID: https://orcid.org/0000-0003-4920-9975)
- José Thyálisson da Costa Silva (ORCID: https://orcid.org/0009-0002-7522-2989)
- Henrique Douglas Melo Coutinho (ORCID: https://orcid.org/0000-0002-6634-4207)
- José Weverton Almeida‐Bezerra (ORCID: https://orcid.org/0000-0002-0966-9750)
- Maraiza Gregório de Oliveira (ORCID: https://orcid.org/0000-0002-2855-641X)
- Priscilla Augusta de Sousa Fernandes (ORCID: https://orcid.org/0000-0001-7357-1013)
- Rafael Pereira da Cruz (ORCID: https://orcid.org/0000-0002-1806-7380)
- Adrielle Rodrigues Costa (ORCID: https://orcid.org/0000-0003-1518-0115)
- Evandro G. da Silva Júnior
- Márcia Vanusa da Silva
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Lavras (BR)
- Universidade Federal de Pernambuco (BR)
- Universidade Regional do Cariri (BR)
- Centro Universitário Católica de Quixadá (BR)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1002/cbdv.202401604
- Citations
- 1
- Primary Topic
- Essential Oils and Antimicrobial Activity
- Type
- article
- Field-Weighted Citation Impact
- 0.35
Funders
- King Saud University