Development of SERS Active Nanoprobe for Selective Adsorption and Detection of Alzheimer’s Disease Biomarkers Based on Molecular Docking
This peptide-probe interaction provides a general enhancement factor and the molecular structure of the misfolded peptides. Secondary structural information may be obtained at the molecular level for specific residues owing to isotope shifts in the Raman spectra. Conjugation of the nanoprobe with Aβ42 selectively detected AD in bodily fluids. The proposed nanoprobes can be easily applied to the detection of Aβ plaques in blood, saliva, and sweat samples.
Authors
- Balázs Zoltán Gulyás (ORCID: https://orcid.org/0000-0001-9295-2460)
- Anshuman Chandra (ORCID: https://orcid.org/0000-0002-2686-3918)
- Vijay K. Goel (ORCID: https://orcid.org/0000-0002-9175-5366)
- Shilpi Agarwal (ORCID: https://orcid.org/0000-0002-1696-2605)
- Umesh Chandra Garnaik
- Parasuraman Padmanabhan (ORCID: https://orcid.org/0000-0003-4112-4600)
Institutions
- Jawaharlal Nehru University (IN)
- Nanyang Technological University (SG)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.2147/ijn.s446212
- Citations
- 5
- Primary Topic
- Nanocluster Synthesis and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- Jawaharlal Nehru University
- Department of Science and Technology, Ministry of Science and Technology, India
- Advanced Instrumentation Research Facility