Combining Bulk and Single Cell RNA-Sequencing Data to Identify Hub Genes of Fibroblasts in Dilated Cardiomyopathy
Ultimately, bulk RNA-seq and scRNA-seq data identified fibroblasts and monocytes as the main cell types implicated in DCM. The highly expressed genes <i>ASPN, FRZB</i>, <i>LUM</i>, and <i>SFRP4</i> in fibroblasts may aid in the mechanistic investigation of DCM.
Authors
- Yangmeng Feng
- Cuixiang Xu (ORCID: https://orcid.org/0000-0001-9498-4175)
- Yaping Li (ORCID: https://orcid.org/0000-0002-9320-8024)
- Qiyu Wang (ORCID: https://orcid.org/0000-0003-4959-7437)
- Guoan Zhang (ORCID: https://orcid.org/0000-0002-9489-6033)
- Xiangrong Zhao
- Xiaoyan Huang (ORCID: https://orcid.org/0000-0003-3104-1887)
Institutions
- Shanxi Medical University (CN)
- Shaanxi Provincial People's Hospital (CN)
- Yan'an University (CN)
- Shanxi Provincial People’s Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-08-01
- DOI
- https://doi.org/10.2147/jir.s470860
- Citations
- 8
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Natural Science Foundation of Shaanxi Province
- Education Department of Shaanxi Province