Genetic, Clinical, Epidemiological, and Immunological Profiling of IgG Response Duration after SARS-CoV-2 Infection
The IgG response against SARS-CoV-2 infection can persist for over six months (long response; LR). However, among 30% of those infected, the duration can be as short as three months or less (short response; SR). The present study assembled serological data on the anti-SARS-CoV-2 IgG response duration of two previous studies and integrated these results with the plasmatic cytokine levels and genetic profile of 10 immune-relevant SNPs that were also previously published, along with the plasmatic total IgG, IgA, and IgM levels, allowing for the genetic, clinical, immunological, and epidemiological aspects of the post-COVID-19 IgG response duration to be understood. The SR was associated with previous mild acute COVID-19 and with an SNP (rs2228145) in <i>IL6R</i> related to low gene expression. Additionally, among the SR subgroup, no statistically significant Spearman correlations were observed between the plasma levels of IL-17A and the Th17 regulatory cytokines IFN-γ (rs = 0.2399; <i>p</i> = 0.1043), IL-4 (rs = 0.0273; <i>p</i> = 0.8554), and IL-2 (rs = 0.2204; <i>p</i> = 0.1365), while among the LR subgroup, weaker but statistically significant Spearman correlations were observed between the plasma levels of IL-17A and IFN-γ (rs = 0.3873; <i>p</i> = 0.0016), IL-4 (rs = 0.2671; <i>p</i> = 0.0328), and IL-2 (rs = 0.3959; <i>p</i> = 0.0012). These results suggest that the Th17 response mediated by the IL-6 pathway has a role in the prolonged IgG response to SARS-CoV-2 infection.
Authors
- Kevin Matheus Lima de Sarges (ORCID: https://orcid.org/0000-0003-0776-6212)
- Luiz Fábio Magno Falcão (ORCID: https://orcid.org/0000-0001-8391-2694)
- Juarez Antônio Simões Quaresma (ORCID: https://orcid.org/0000-0002-6267-9966)
- Mioni Thieli Figueiredo Magalhães de Brito (ORCID: https://orcid.org/0000-0001-8165-8629)
- Fabíola Brasil Barbosa Rodrigues (ORCID: https://orcid.org/0000-0002-4294-4099)
- Antônio Carlos Rosário Vallinoto (ORCID: https://orcid.org/0000-0003-1135-6507)
- Izaura Maria Vieira Cayres Vallinoto (ORCID: https://orcid.org/0000-0003-1408-8384)
- Flávia Póvoa da Costa (ORCID: https://orcid.org/0000-0002-5667-0754)
- Maria Alice Freitas Queiroz (ORCID: https://orcid.org/0000-0003-2014-2770)
- Camille Ferreira de Oliveira (ORCID: https://orcid.org/0000-0003-3859-0061)
- Mauro de Meira Leite (ORCID: https://orcid.org/0000-0002-3620-3470)
- Pablo Fabiano Moura das Neves (ORCID: https://orcid.org/0000-0003-3531-5582)
- Daniele Freitas Henriques (ORCID: https://orcid.org/0000-0001-9576-6620)
- Eduardo José Melo dos Santos (ORCID: https://orcid.org/0000-0001-5134-5648)
- Gabriel dos Santos Pereira Neto (ORCID: https://orcid.org/0000-0002-7825-9384)
- Maria de Nazaré do Socorro de Almeida Viana (ORCID: https://orcid.org/0000-0002-8495-9619)
- Rosilene da Silva (ORCID: https://orcid.org/0000-0001-8913-2971)
- Giselle Maria Rachid Viana (ORCID: https://orcid.org/0000-0003-1771-7211)
- Marcos Henrique Damasceno Cantanhede (ORCID: https://orcid.org/0000-0003-2263-8403)
- Erika Ferreira dos Santos (ORCID: https://orcid.org/0000-0001-9188-1066)
- Andréa Luciana Soares da Silva (ORCID: https://orcid.org/0000-0003-4299-0252)
- Matheus Holanda do Nascimento
- Alice Maciel Rodrigues
Institutions
- Universidade do Estado do Pará (BR)
- Ministério da Saúde (BR)
- Universidade Federal do Pará (BR)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2024-08-10
- DOI
- https://doi.org/10.3390/ijms25168740
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade Federal do Pará