The oncogenic fusion protein EML4-NTRK3 requires three salt bridges for stability and biological activity
These data suggest potential therapeutic strategies for Infantile Fibrosarcoma cases bearing EML4-NTRK3 fusion through inhibition of salt bridge interactions and disruption of multimerization.
Authors
- April N. Meyer
- Wei Yang (ORCID: https://orcid.org/0000-0002-9063-2794)
- Daniel J. Donoghue (ORCID: https://orcid.org/0000-0002-4546-2175)
- Zian Jiang
Institutions
- University of California San Diego (US)
Publication Details
- Journal
- Heliyon
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e36278
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- UC San Diego Foundation
- University of California, San Diego
- National Institute of Neurological Disorders and Stroke