Insights into the molecular basis of gastric mucosa as a first step for using Raman microscopy in paediatrics
Recent advances in endoscopic technology have allowed detailed observation of the gastric mucosa, including Raman microscopy and spectroscopy. To explore the possibilities for future diagnostic use, we discuss the measurements and molecular markers found in this tissue. The Raman spectra of 16 samples of antral mucosa and 16 samples of corpus gastric mucosa obtained from healthy donors were analysed. A stable protocol for measuring reproducible spectra was established. These data suggest that many biomarkers can be used for the rapid analysis of metabolic states and future investigations into the pathogenesis of gastrointestinal diseases.
Authors
- Jan Schwarz (ORCID: https://orcid.org/0000-0003-4214-8858)
- Л. В. Ванькова (ORCID: https://orcid.org/0000-0002-9358-5049)
- Magdaléna Daumová (ORCID: https://orcid.org/0000-0002-2241-1383)
- Petr Bouř (ORCID: https://orcid.org/0000-0001-8469-1686)
- Jiří Bufka (ORCID: https://orcid.org/0009-0004-7853-195X)
- Josef Sýkora
Institutions
- Charles University (CZ)
- Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry (CZ)
Publication Details
- Journal
- Heliyon
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e36231
- Primary Topic
- Spectroscopy Techniques in Biomedical and Chemical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Univerzita Karlova v Praze
- Grantová Agentura České Republiky
- Lékařská Fakulta v Plzni, Univerzita Karlova
- Ústav organické chemie a biochemie Akademie věd České republiky