β-Cell Dedifferentiation in HOMA-βlow and HOMA-βhigh Subjects
Our findings emphasize the contribution of β-cell dedifferentiation to β-cell dysfunction in humans. Bach2 induction in β-cells with higher frequency of dedifferentiation observed in HOMA-βlow subjects reinforces its distinctive role as a pharmaceutical target of β-cell dedifferentiation for the treatment of people with diabetes.
Authors
- Jiajun Sun (ORCID: https://orcid.org/0000-0001-5529-6660)
- Fuyun Kang
- Zhuo Zhang (ORCID: https://orcid.org/0000-0002-3946-0720)
- Hui Fu (ORCID: https://orcid.org/0000-0002-4303-373X)
- Jun Zhang (ORCID: https://orcid.org/0000-0002-2428-9772)
- Qidi Wang (ORCID: https://orcid.org/0000-0003-0664-7502)
Institutions
- Shanghai Jiao Tong University (CN)
- National Health and Family Planning Commission (CN)
- Beijing United Family Hospital (CN)
- Ruijin Hospital (CN)
- Center for Life Sciences (CN)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2024-08-10
- DOI
- https://doi.org/10.1210/clinem/dgae538
- Citations
- 3
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- National Natural Science Foundation of China