Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer
Our findings revealed a previously unknown association between galectin-3 and TREM2 in TAMs of lung cancer, and suggested simultaneous inhibition of galectin3 and TREM2 as potent therapeutic approach for lung cancer therapy.
Authors
- Guanmin Jiang (ORCID: https://orcid.org/0000-0002-0397-1860)
- Yongjian Wu (ORCID: https://orcid.org/0000-0003-1234-8760)
- Xi Huang (ORCID: https://orcid.org/0000-0002-4829-8390)
- Qiaohua Wang (ORCID: https://orcid.org/0000-0003-3404-6907)
Institutions
- Sun Yat-sen University (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s13046-024-03124-6
- Citations
- 18
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 4.33
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province