Interleukin‐33 and liver natural killer cells: A novel perspective on antitumor activity in liver fibrosis
Our study revealed a critical relationship between liver fibrosis and compromised tumor immunity, emphasizing the potential interference of IL-33 with NK cell function. These insights advocate for advanced immunostimulatory therapies targeting cytokines, such as IL-33, aiming to bolster the hepatic immune response against HCC in the context of liver fibrosis.
Authors
- Toshihiro Nakayama (ORCID: https://orcid.org/0000-0001-8216-0371)
- Hideki Ohdan (ORCID: https://orcid.org/0000-0002-9066-1288)
- Carlos O. Esquivel (ORCID: https://orcid.org/0000-0003-0871-0480)
- Kouki Imaoka (ORCID: https://orcid.org/0000-0001-8972-5777)
- Masahiro Ohira (ORCID: https://orcid.org/0000-0002-5433-5303)
- Olivia M. Martinez (ORCID: https://orcid.org/0000-0002-2798-0251)
- Sheri M. Krams (ORCID: https://orcid.org/0000-0002-6049-5119)
- Shinichiro Yokota
- Yuki Imaoka (ORCID: https://orcid.org/0000-0003-0882-5341)
- Takuya Yano (ORCID: https://orcid.org/0000-0002-2833-2627)
- Miho Akabane (ORCID: https://orcid.org/0000-0002-6705-5730)
- Tetsuya Tajima (ORCID: https://orcid.org/0000-0002-6538-7408)
- Tomoaki Bekki (ORCID: https://orcid.org/0000-0003-0155-2360)
- Yuka Tanaka (ORCID: https://orcid.org/0000-0001-9510-3421)
- Ryosuke Nakano
- Kazunari Sasaki
Institutions
- Hiroshima University (JP)
- Hiroshima University Hospital (JP)
- Stanford University (US)
Publication Details
- Journal
- Hepatology Research
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1111/hepr.14102
- Citations
- 9
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 2.16
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science