Continuous sampling of healthy and mastitic quarters of lactating cattle by ultrafiltration after intramammary ceftiofur hydrochloride administration
Significant inter- and intracow variability and lower daily milk weights may overestimate ceftiofur concentrations available within the cistern. The pharmacokinetic (PK) parameters reported in milk ultrafiltrate will help establish a link between the PK and the corresponding drug effect, potentially providing a meaningful rationale for the selection of a safe and effective dose in cows with mastitis.
Authors
- Derek M. Foster (ORCID: https://orcid.org/0000-0002-6859-9801)
- Hannah J. Sylvester
- Danielle A. Mzyk (ORCID: https://orcid.org/0000-0002-9834-2089)
- Megan E. Jacob (ORCID: https://orcid.org/0000-0002-6719-4044)
- Ronald E. Baynes (ORCID: https://orcid.org/0000-0002-7920-9338)
- Jennifer L. Halleran (ORCID: https://orcid.org/0000-0002-1733-6307)
- Claire B. Giles
Institutions
- North Carolina State University (US)
Publication Details
- Journal
- Journal of Veterinary Internal Medicine
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1111/jvim.17155
- Citations
- 2
- Primary Topic
- Milk Quality and Mastitis in Dairy Cows
- Type
- article
- Field-Weighted Citation Impact
- 1.14