Screening a neurotransmitter-receptor-related inhibitor library identifies clomipramine HCl as a potential antiviral compound against Japanese encephalitis virus
This study highlights the importance of clomipramine HCl as a promising approach for JEV infection protection, which may lead to new host-directed antiviral approaches to such mosquito-borne viruses.
Authors
- Shengbo Cao (ORCID: https://orcid.org/0000-0002-9787-7882)
- Youhui Si (ORCID: https://orcid.org/0000-0001-8909-221X)
- Shuo Zhu
- Bibo Zhu (ORCID: https://orcid.org/0000-0002-1187-4526)
- Wenjing Zhu (ORCID: https://orcid.org/0000-0003-0958-0905)
- Huanchun Chen (ORCID: https://orcid.org/0000-0003-0680-5953)
- Xugang Wang (ORCID: https://orcid.org/0000-0002-1860-7439)
- Yixin Liu (ORCID: https://orcid.org/0000-0003-4401-9291)
- Jing Ye (ORCID: https://orcid.org/0000-0003-3507-5355)
- Zikai Zhao
- Qi Li (ORCID: https://orcid.org/0000-0002-0060-3376)
Institutions
- Huazhong Agricultural University (CN)
- Shanghai Zhangjiang Laboratory (CN)
Publication Details
- Journal
- Infectious Medicine
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1016/j.imj.2024.100130
- Citations
- 4
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 2.17
Funders
- National Natural Science Foundation of China
- Huazhong Agricultural University
- National Key Research and Development Program of China