Hippocampal temporal dynamics and spatial heterogeneity unveil vulnerability markers in the offspring of bipolar patients
Overall, we observed alterations of large-scale functional brain networks associated with decreased cognitive control flexibility and disrupted somatomotor, saliency, and emotion processing in BD. Interestingly, BDoff presented an intermediate phenotype between BD and HC, suggesting that dFC of hippocampal subregions might represent a marker of vulnerability to BD.
Authors
- Dimitri Van De Ville (ORCID: https://orcid.org/0000-0002-2879-3861)
- Camille Piguet (ORCID: https://orcid.org/0000-0003-4317-0918)
- Farnaz Delavari (ORCID: https://orcid.org/0000-0003-2990-4372)
- Luigi Francesco Saccaro (ORCID: https://orcid.org/0000-0001-6703-6890)
Institutions
- University of Geneva (CH)
- University Hospital of Geneva (CH)
- École Polytechnique Fédérale de Lausanne (CH)
Publication Details
- Journal
- Bipolar Disorders
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1111/bdi.13487
- Citations
- 8
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.08
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Center of Competence in Research Chemical Biology