LINC00460/miR-186-3p/MYC feedback loop facilitates colorectal cancer immune escape by enhancing CD47 and PD-L1 expressions
The LINC00460/miR-186-3p/MYC feedback loop promotes CRC cell immune escape and subsequently facilitates CRC proliferation and metastasis. Our findings provide novel insight into LINC00460 as a CRC immune regulator, and provide a potential therapeutic target for CRC patients.
Authors
- Ping Yang (ORCID: https://orcid.org/0009-0007-3471-3059)
- Wenlong Liang (ORCID: https://orcid.org/0009-0004-2528-5935)
- Wanglin Li (ORCID: https://orcid.org/0000-0002-2103-0271)
- Fei Shen
- Jianchang Wei (ORCID: https://orcid.org/0000-0002-3675-9460)
- Jie Cao (ORCID: https://orcid.org/0000-0003-3604-5764)
- Lan Dong (ORCID: https://orcid.org/0000-0002-3560-4053)
- He Hu
- Feng He (ORCID: https://orcid.org/0009-0005-9798-0248)
- Qingqing Luo (ORCID: https://orcid.org/0000-0002-5403-2388)
- Qing Huang (ORCID: https://orcid.org/0000-0002-7086-028X)
- Sheng Zhao (ORCID: https://orcid.org/0000-0002-0813-4228)
- Qiang Wang (ORCID: https://orcid.org/0000-0002-1615-662X)
Institutions
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou First People's Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1186/s13046-024-03145-1
- Citations
- 11
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- National Natural Science Foundation of China