Pretreatment with Indole-3-Propionic Acid Attenuates Lipopolysaccharide-Induced Cardiac Dysfunction and Inflammation Through the AhR/NF-κB/NLRP3 Pathway
Our study revealed that IPA improved left heart dysfunction and myocardial inflammation caused by sepsis via AhR/NF-κB/NLRP3 signaling, suggesting that IPA is a potential therapy for septic cardiomyopathy.
Authors
- Yiqiong Zhang (ORCID: https://orcid.org/0009-0007-8836-6259)
- Xiaojuan Fan (ORCID: https://orcid.org/0000-0001-9255-1544)
- Shanshan Li (ORCID: https://orcid.org/0000-0002-9021-8470)
- Yue Wu (ORCID: https://orcid.org/0000-0002-0084-2510)
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-08-01
- DOI
- https://doi.org/10.2147/jir.s466777
- Citations
- 19
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 4.57