Cover Feature: Backbone Modification in a Protein Hydrophobic Core (Chem. Eur. J. 45/2024)

The hydrophobic core of a protein, made up of side chains buried away from water in the folded state, is a crucial element of protein structure. New results show that artificial backbone connectivity can be accommodated in the core of a tertiary fold with minimal impact on folded structure or stability. More information can be found in the Research Article by Y. Lin and W. S. Horne (DOI: 10.1002/chem.202401890).