Effects of indoor environments and outdoor air pollutants in residential areas on acute exacerbation in patients with severe asthma
This study aimed to determine the effects of indoor environment (IE) and outdoor air pollutants (OAPs) in residential areas on acute exacerbation (AE) in patients with severe asthma. A total of 115 participants were recruited. To characterize IE, we used structured questionnaires and estimated OAP concentrations using a land-use regression model. Participants who were exposed to passive smoking and lived in houses where the kitchen and living room were not separated showed a significantly higher rate of AE (<i>p</i> = 0.014 and 0.0016, respectively). The mean concentration of PM<sub>2.5</sub> in residential areas during the last 3 years was significantly higher in participants with AE than that in those without AE (19.8 ± 3.1 <i>vs</i>. 21.0 ± 2.5 µg/m<sup>3</sup>, <i>p</i> = 0.033). Moreover, the serum level of 8-hydroxy-2'-deoxyguanosine significantly increased in participants with AE compared to those without AE (56.9 ± 30.0 <i>vs</i>. 94.7 ± 44.5 ng/mL, <i>p</i> = 0.0047) suggesting enhanced oxidative stress in those with AE.
Authors
- Min‐Hye Kim (ORCID: https://orcid.org/0000-0002-1775-3733)
- Min‐Suk Yang (ORCID: https://orcid.org/0000-0002-9861-0530)
- Heung‐Woo Park (ORCID: https://orcid.org/0000-0002-6970-3228)
- Da Woon Sim (ORCID: https://orcid.org/0000-0002-9723-0720)
- Hwan‐Cheol Kim (ORCID: https://orcid.org/0000-0002-3635-1297)
- Byung‐Keun Kim (ORCID: https://orcid.org/0000-0001-5147-6306)
- Young‐Hee Nam (ORCID: https://orcid.org/0000-0001-8759-2982)
- Ji‐Su Shim (ORCID: https://orcid.org/0000-0002-8846-0364)
- So Ri Kim (ORCID: https://orcid.org/0000-0002-6074-9158)
- Young‐Il Koh (ORCID: https://orcid.org/0000-0002-5100-9473)
- Dong‐Wook Lee (ORCID: https://orcid.org/0000-0002-4023-3269)
- Sang-Heon Kim
- Young‐Soo Lee (ORCID: https://orcid.org/0009-0004-8738-0612)
Institutions
- Ewha Womans University (KR)
- Seoul National University (KR)
- Inha University (KR)
- Korea University (KR)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- Chonnam National University Hospital (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Ajou University Hospital (KR)
- Ewha Womans University Medical Center (KR)
- Inha University Hospital (KR)
- Hanyang University (KR)
- Dong-A University (KR)
- Jeonbuk National University (KR)
Publication Details
- Journal
- International Journal of Environmental Health Research
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1080/09603123.2024.2390474
- Citations
- 1
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.31
Funders
- Korea National Institute of Health