Anti‐Ri‐antibodies associated paraneoplastic myelopathy revealing a woman's breast cancer: A case report
Abstract Paraneoplastic myelopathy (PM) is an enigmatic immune‐mediated disorder rarely associated with breast cancer (BC) and anti‐Ri antibodies. Sometimes diagnosis is difficult due to the heterogeneity of symptoms and the timing of their onset. Herein, we report the case of a woman presenting with cervical myelopathy causing spastic left hemiplegia and painful spasms. Diagnosis of PM was confirmed through the positivity of well‐characterized onconeural antibodies (anti‐Ri) and the discovery of BC after a clinical examination and multiple investigations. We highlight, through this case, the importance of onconeural antibodies in the diagnosis of paraneoplastic neurological syndromes and associated cancer.
Authors
- Rania Zouari
- Jihen Abdellatif
- Ahlem Ben Hmid (ORCID: https://orcid.org/0000-0001-9766-920X)
- Mèlika Ben Ahmed (ORCID: https://orcid.org/0000-0002-3179-1648)
- Imen Zamali (ORCID: https://orcid.org/0000-0002-0438-6807)
- Samia Ben Sassi (ORCID: https://orcid.org/0000-0002-1002-5979)
- Mohamed Zakaria Saeid
Institutions
- Tunis University (TN)
- Institut Pasteur de Tunis (TN)
- National Institute of Neurology Mongi-Ben Hamida (TN)
- Faculté de médecine de Tunis
Publication Details
- Journal
- Neurology and Clinical Neuroscience
- Published
- 2024-08-12
- DOI
- https://doi.org/10.1111/ncn3.12850
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00