Activation of neurotoxic A1‐reactive astrocytes by SFTS virus infection accelerates fatal brain damage in IFNAR1<sup>‐/‐</sup> mice
Severe fever with thrombocytopenia syndrome (SFTS) has a high mortality rate compared to other infectious diseases. SFTS is particularly associated with a high risk of mortality in immunocompromised individuals, while most patients who die of SFTS exhibit symptoms of severe encephalitis before death. However, the region of brain damage and mechanisms by which the SFTS virus (SFTSV) causes encephalitis remains unknown. Here, we revealed that SFTSV infects the brainstem and spinal cord, which are regions of the brain associated with respiratory function, and motor nerves in IFNAR1<sup>-/-</sup> mice. Further, we show that A1-reactive astrocytes are activated, causing nerve cell death, in infected mice. Primary astrocytes of SFTSV-infected IFNAR1<sup>-/-</sup> mice also induced neuronal cell death through the activation of A1-reactive astrocytes. Herein, we showed that SFTSV induces fatal neuroinflammation in the brain regions important for respiratory function and motor nerve, which may underlie mortality in SFTS patients. This study provides new insights for the treatment of SFTS, for which there is currently no therapeutic approach.
Authors
- H. Park
- Seung Pil Yun (ORCID: https://orcid.org/0000-0002-5151-8534)
- Mingyo Kim (ORCID: https://orcid.org/0000-0003-3744-8522)
- Chieun Song (ORCID: https://orcid.org/0000-0001-5501-4053)
- Hyun‐Jeong Kim
- Seong-Jae Kim (ORCID: https://orcid.org/0000-0002-4143-3959)
- Kyung‐Wook Hong (ORCID: https://orcid.org/0000-0002-3227-9558)
- In‐Soon Roh (ORCID: https://orcid.org/0000-0003-0685-5651)
- Bina Lee (ORCID: https://orcid.org/0000-0002-0910-3677)
- Jinsung Yang (ORCID: https://orcid.org/0000-0002-9731-1002)
- Han Sol Yoo
- Min Gi Jo (ORCID: https://orcid.org/0000-0002-2863-6989)
- Seon‐Hee Kim (ORCID: https://orcid.org/0000-0003-1099-1728)
- Hyemin Seong (ORCID: https://orcid.org/0000-0003-0952-8197)
- Young Jin Kim (ORCID: https://orcid.org/0000-0002-1593-7678)
- Min Young Lee (ORCID: https://orcid.org/0000-0003-0067-2803)
- Sang Won Park (ORCID: https://orcid.org/0000-0002-6149-5284)
- Jeong Hyun Lee (ORCID: https://orcid.org/0000-0003-0504-0119)
- Minkyeong Kim (ORCID: https://orcid.org/0000-0001-8376-867X)
- Hye Jung Kim (ORCID: https://orcid.org/0000-0002-7067-6810)
- Ha Nyeoung Choi
- Da-Seul Seong
Institutions
- Gyeongsang National University (KR)
- Kyungpook National University (KR)
- Kyung Hee University (KR)
- Gyeongsang National University Hospital (KR)
- Animal and Plant Quarantine Agency (KR)
Publication Details
- Journal
- Journal of Medical Virology
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/jmv.29854
- Citations
- 5
- Primary Topic
- Viral Infections and Vectors
- Type
- article
- Field-Weighted Citation Impact
- 1.95
Funders
- National Research Foundation of Korea
- Animal and Plant Quarantine Agency