Suppression of CGRP and TRPV1 Expression in Dorsal Root Ganglia of Knee Osteoarthritis Rats by Huojing Decoction via TrkA/MKK3/6/p38 Pathway
Our data suggested that Huojing decoction can alleviate inflammation in KOA pain rats. Additionally, it can inhibit the expression of TrKA, MKK3/6 and p38 signaling pathways, indicating its analgesic effect on KOA pain rats.
Authors
- Yinyin Guo
- Xin Wang (ORCID: https://orcid.org/0000-0002-6969-6152)
- Biao Zhang (ORCID: https://orcid.org/0000-0001-8334-5175)
- Jianxue Qian
- Mei Fang (ORCID: https://orcid.org/0000-0002-8816-475X)
- Yi Song (ORCID: https://orcid.org/0000-0003-2334-4896)
- Xinchao Jiang (ORCID: https://orcid.org/0009-0003-1556-8942)
Institutions
- Suzhou Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-08-01
- DOI
- https://doi.org/10.2147/jir.s472341
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Program of Suzhou