Design and Development of Floating Tablets of Ranitidine hydrochloride by Using Natural Polymers

The objective of this research is to design and develop controlled release floating tablets of Ranitidine hydrochloride to enhance bioavailability and therapeutic efficacy.The tablets were formulated using a direct compression method, incorporating either treated ghee residue or oyster mushroom powder as binders, and sodium bicarbonate as an effervescent agent.The powder blend was evaluated for flow properties, and the tablets were physically characterized for weight variation, hardness, and friability, confirming their physical integrity.All formulations exhibited immediate buoyancy upon placement in the beaker, maintaining floatation for over 14 hours.It was observed that the carbon dioxide generated by sodium bicarbonate in the presence of the dissolution medium (0.1N HCl) was trapped in the polymer gel matrix formed by polymer hydration, reducing the density (<1) and enabling tablet buoyancy.The correlation coefficient values (r) indicated that the dissolution profiles adhered to zero-order kinetics, and the drug release mechanism was governed by the Peppas model.The n values (n>0.5)indicated that drug release was predominantly controlled by non-Fickian diffusion.Formulations utilizing treated ghee residue demonstrated prolonged release compared to those with oyster mushroom powder.Among all formulations, the F3 formulation, comprising a drug to treated ghee residue ratio of 1:1.5, was identified as the optimal formulation to achieve the desired drug release profile.