Anesthesiology

The Hypotension Prediction Index software is a machine learning algorithm that detects physiologic changes that may lead to hypotension; however, the original validation used a case control (backward) analysis that has been suggested to be biased. In this issue of Anesthesiology, Davies et al. conducted a cohort (forward) analysis and compared it to the original validation technique. It has also been recently suggested that the index algorithm is highly correlated with the mean arterial pressure itself. Therefore, Mulder et al. compared the index with mean arterial pressure–based prediction methods. In an accompanying editorial, Vistisen et al. analyze these new studies and the evaluation of artificial intelligence use in prediction models. Cover illustration: A. Johnson, Vivo Visuals Studio.