Causal effects of skin microbiota on intervertebral disk degeneration, low back pain and sciatica: a two-sample Mendelian randomization study
This study identified a potential causal relationship between skin microbiota and IVDD, LBP, and sciatica. No evidence suggests skin-derived P.acnes is a risk factor for IVDD, LBP and sciatica. At the same time, IVDD can potentially cause an increase in P.acnes abundance, which supports the contamination theory.
Authors
- Houcong Chen
- Zhenxin Huo
- Baoshan Xu (ORCID: https://orcid.org/0000-0003-4121-1835)
- Shengbo Huang (ORCID: https://orcid.org/0009-0006-2231-1418)
- Yuchao Jia
Institutions
- Tianjin University (CN)
- Tianjin Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1186/s13018-024-04980-w
- Citations
- 3
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Tianjin Municipal Health Commission