Efficacy and safety of trimodulin in patients with severe COVID-19: results from a randomised, placebo-controlled, double-blind, multicentre, phase II trial (ESsCOVID)
Although there was no difference in the primary outcome in the overall population, observations in a subgroup of patients with early systemic inflammation suggest that trimodulin may have potential in this setting that warrants further investigation. ESSCOVID WAS REGISTERED PROSPECTIVELY AT CLINICALTRIALS.GOV ON OCTOBER 6, 2020.: NCT04576728.
Authors
- Markus Ruehle
- Javier Carbone (ORCID: https://orcid.org/0000-0003-2056-0534)
- И. Г. Гордеев (ORCID: https://orcid.org/0000-0002-3233-4369)
- Sergey Nikolaevich Avdeev (ORCID: https://orcid.org/0000-0002-5999-2150)
- Muriel Fartoukh
- Alexander Staus
- Claudio Stadnik (ORCID: https://orcid.org/0000-0002-0686-4833)
- Guillaume Thiéry (ORCID: https://orcid.org/0000-0002-8786-9061)
- Patrick Langohr
- Iris Bobenhausen
- Thomas Häder
- Valéria Cristina Resende Aguiar (ORCID: https://orcid.org/0009-0004-9950-0415)
- Д. Н. Проценко (ORCID: https://orcid.org/0000-0002-5166-3280)
- Alina Agafina
- Corina C. Heinz (ORCID: https://orcid.org/0000-0003-1702-3914)
- Rita Pellegrini
- Sabrina Weißmüller
- Maria Rossovskaya
- Miquel Ferrer (ORCID: https://orcid.org/0000-0001-8171-6673)
- Antoní Torres (ORCID: https://orcid.org/0000-0002-8643-2167)
- Andrea Wartenburg-Demand
- Jean-François Timsit
- Ludhmila Abrahão Hajjar
- Jörg Schüttrumpf (ORCID: https://orcid.org/0000-0002-8855-4096)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Sechenov University (RU)
- Hospital General Universitario Gregorio Marañón (ES)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Biotest (Germany) (DE)
- City Hospital No. 40 (RU)
- Institute Cancer De La Loire Lucien Neuwirth (FR)
- Hospital Clínic de Barcelona (ES)
- Santa Casa de Misericórdia de Marília (BR)
- Grifols (Spain) (ES)
- City Clinical Hospital (RU)
- Hôpital Bichat-Claude-Bernard (FR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Centre Hospitalier Universitaire de Saint-Étienne (FR)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Hôpital Tenon (FR)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- European journal of medical research
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1186/s40001-024-02008-x
- Citations
- 5
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- Assistance publique-Hôpitaux de Paris
- I.M. Sechenov First Moscow State Medical University
- Sorbonne Université