Three-Component Synthesis of 5-Aryl(hetaryl)-4-aroyl-1-isobutyl-3-hydroxy-3-pyrroline-2-ones
A series of new 5-aryl(hetaryl)-4-aroyl-1-isobutyl-3-hydroxy-3-pyrrolin-2-ones were synthesized by reacting methyl esters of aroylpyruvic acids with aromatic (heterocyclic) aldehydes and isobutylamine in dioxane. Antimicrobial activity of the obtained compounds was studied in vitro against Staphylococcus aureus, Escherichia coli and Candida albicans strains.
Authors
- E. A. Buldakova (ORCID: https://orcid.org/0000-0003-2489-2261)
- В. Л. Гейн (ORCID: https://orcid.org/0000-0002-8512-0399)
- I. G. Mokrushin (ORCID: https://orcid.org/0000-0002-4095-8366)
- Д. Г. Дианова (ORCID: https://orcid.org/0000-0002-0170-1824)
- Н. В. Носова (ORCID: https://orcid.org/0000-0001-6380-2543)
- O. O. Senokosova
Institutions
- Moscow Power Engineering Institute (RU)
- Solikamsk State Pedagogical Institute (RU)
- Perm State Pharmaceutical Academy (RU)
Publication Details
- Journal
- Журнал Общей Химии
- Published
- 2024-08-13
- DOI
- https://doi.org/10.31857/s0044460x24030039
- Citations
- 1
- Primary Topic
- Synthesis and Characterization of Pyrroles
- Type
- article
- Field-Weighted Citation Impact
- 0.25