The metastasis-promoting P1597L mutation in PlexinB1 enhances Ras activity
These results suggest that the clinically relevant P1597L mutation in PlexinB1 may transform PlexinB1 from a suppressor to a driver of metastasis in mouse models of prostate cancer by reducing the RapGAP activity of PlexinB1, leading to Ras activation. These findings highlight the PlexinB1-Rap-Ras pathway for therapeutic intervention in prostate cancer.
Authors
- Magali Williamson (ORCID: https://orcid.org/0000-0002-7183-7495)
- Ritu Garg (ORCID: https://orcid.org/0009-0007-0291-6839)
Institutions
- King's College London (GB)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1186/s12885-024-12762-0
- Primary Topic
- Axon Guidance and Neuronal Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00