Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression
Our work demonstrates that the bidirectional interplay between sympathetic nerves and NGF-expressing CAFs drives colorectal tumorigenesis. This study also offers novel mechanistic insights into catecholamine action in colorectal cancer. Inhibiting the neuro-mesenchymal interaction by TRK blockade could be a potential strategy for treating colorectal cancer.
Authors
- Xiaofei Zhi (ORCID: https://orcid.org/0000-0003-1367-7638)
- Atsushi Ogura (ORCID: https://orcid.org/0000-0002-6560-1806)
- Atsushi Enomoto (ORCID: https://orcid.org/0000-0002-9206-6116)
- Daniel L. Worthley (ORCID: https://orcid.org/0000-0003-0374-9124)
- Jonathan S. LaBella
- Biyun Zheng (ORCID: https://orcid.org/0000-0001-7680-8661)
- Yosuke Ochiai (ORCID: https://orcid.org/0000-0003-3069-1175)
- Susan L. Woods (ORCID: https://orcid.org/0000-0002-8955-2017)
- Quin T. Waterbury (ORCID: https://orcid.org/0000-0001-6394-9895)
- Leah Zamechek (ORCID: https://orcid.org/0000-0003-2863-2950)
- Tadashi Iida (ORCID: https://orcid.org/0000-0001-5491-6012)
- Jin Qian (ORCID: https://orcid.org/0000-0002-9684-1685)
- Ermanno Malagola (ORCID: https://orcid.org/0000-0001-9294-3097)
- Hiroki Kobayashi (ORCID: https://orcid.org/0000-0002-1717-4870)
- Feijing Wu (ORCID: https://orcid.org/0000-0001-9198-7960)
- Ru‐Hong Tu (ORCID: https://orcid.org/0000-0002-7491-3879)
- Timothy C. Wang (ORCID: https://orcid.org/0000-0001-5730-3019)
- Ruth A. White (ORCID: https://orcid.org/0000-0002-4274-4468)
Institutions
- Columbia University Irving Medical Center (US)
- Center for Digestive and Liver Diseases (US)
- South Australian Health and Medical Research Institute (AU)
- Union Hospital (CN)
- The University of Adelaide (AU)
- Nagoya University (JP)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0287
- Citations
- 47
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 18.12
Funders
- U.S. Department of Defense
- Japan Agency for Medical Research and Development
- National Institutes of Health
- Japan Society for the Promotion of Science
- Mega-projects of Science Research for the 10th Five-Year Plan
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases