Cortical inexcitability in ALS: correlating a clinical phenotype
The present study established that cortical inexcitability was associated with a phenotype characterised by prominent UMN signs, greater motor and functional decline, and a younger age of onset. The present findings inform patient management and could improve patient stratification in clinical trials.
Authors
- Nimeshan Geevasinga (ORCID: https://orcid.org/0000-0002-9338-0318)
- Nathan Pavey (ORCID: https://orcid.org/0000-0001-9636-4391)
- Mana Higashihara (ORCID: https://orcid.org/0000-0001-8015-2028)
- Mehdi van den Bos (ORCID: https://orcid.org/0000-0003-0381-917X)
- Steve Vucic (ORCID: https://orcid.org/0000-0002-8323-873X)
- Parvathi Menon (ORCID: https://orcid.org/0000-0001-6935-5852)
- Andrew Hannaford
Institutions
- The University of Sydney (AU)
- Concord Repatriation General Hospital (AU)
- Westmead Hospital (AU)
- Tokyo Metropolitan Geriatric Hospital (JP)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1136/jnnp-2024-333928
- Citations
- 7
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 2.58
Funders
- Motor Neurone Disease Research Australia
- National Health and Medical Research Council