PPAR beta/gamma mediates the antihypertensive activity of a synbiotic preparation of Bifidobacterium lactis and Lactobacillus acidophilus in spontaneous hypertensive rats
The results of the study suggest that the novel synbiotic preparation reduces blood pressure by altering the composition of the intestinal microbiota, regulating PPAR signaling pathway, and activating the PPARβ and PPARγ cascade reactions in the ileum.
Authors
- Ying Huang
- Yu‐Feng Chen (ORCID: https://orcid.org/0000-0002-7935-5941)
- Wei Gong (ORCID: https://orcid.org/0009-0008-9817-5736)
- Fang Wang (ORCID: https://orcid.org/0000-0002-8808-8531)
Institutions
- General Hospital of Shenyang Military Region (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e36157
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Natural Science Foundation of Shenyang City
- Natural Science Foundation of Liaoning Province
- Shenyang Science and Technology Bureau