Gut microbiota-derived indole-3-propionic acid alleviates diabetic kidney disease through its mitochondrial protective effect via reducing ubiquitination mediated-degradation of SIRT1
Our findings underscore the potential of the microbial metabolite IPA to attenuate DKD progression, offering novel insights and potential therapeutic strategies for its management.
Authors
- Yan Zeng (ORCID: https://orcid.org/0000-0002-4083-0127)
- Junling Gu (ORCID: https://orcid.org/0000-0002-8451-7992)
- Fang‐Yuan Teng (ORCID: https://orcid.org/0000-0002-9564-0961)
- Chunxia Jiang (ORCID: https://orcid.org/0000-0002-3880-9388)
- Weimin Huang (ORCID: https://orcid.org/0000-0002-6691-3369)
- Man Guo (ORCID: https://orcid.org/0000-0001-7646-669X)
- Fanjie Zhang
- Xiaozhen Tan (ORCID: https://orcid.org/0000-0002-7318-7406)
- Betty Yuen Kwan Law (ORCID: https://orcid.org/0000-0002-8926-3960)
- Chunxiang Zhang (ORCID: https://orcid.org/0000-0002-7676-6630)
- Xinyue Li
- Jiao Chen (ORCID: https://orcid.org/0000-0003-2367-4369)
- Xiumei Ma
- Qi Wu (ORCID: https://orcid.org/0000-0001-9212-4139)
- Long Yang (ORCID: https://orcid.org/0000-0003-2597-4859)
- Yong Xu
Institutions
- Macau University of Science and Technology (MO)
- University of Electronic Science and Technology of China (CN)
- China National Nuclear Corporation (CN)
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- First Affiliated Hospital of Sichuan Medical University (CN)
- Sichuan Provincial Hospital of Traditional Chinese Medicine (CN)
- Second People’s Hospital of Yibin (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1016/j.jare.2024.08.018
- Citations
- 36
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 12.39