The impact of breastfeeding on the preterm infant’s microbiome and metabolome: a pilot study
The microbiome and metabolome is altered in the infant's saliva but not their stool, and in mother's milk when feeds are transitioned from tube to oral/breastfeeding. We assessed the relationship between the gut and oral microbiome/metabolome with the milk microbiome/metabolome over a longitudinal period of time in preterm babies. Metabolites that changed in the infants saliva after the initiation of oral feeds have the potential to be used as biomarkers for disease risk.
Authors
- Sarah M. Allard (ORCID: https://orcid.org/0000-0001-7626-0472)
- Se Jin Song (ORCID: https://orcid.org/0000-0003-0750-5709)
- Sydney Leibel (ORCID: https://orcid.org/0000-0001-9857-7657)
- Gertrude Ecklu-Mensah (ORCID: https://orcid.org/0000-0003-1770-3071)
- Shiyu S. Bai-Tong
- Sandra L. Leibel (ORCID: https://orcid.org/0000-0001-6867-2477)
- Jack A. Gilbert (ORCID: https://orcid.org/0000-0001-7920-7001)
- Concepcion Sanchez
- Lars Bode (ORCID: https://orcid.org/0000-0002-9914-9571)
- Pieter C. Dorrestein (ORCID: https://orcid.org/0000-0002-3003-1030)
- David J. Gonzalez (ORCID: https://orcid.org/0000-0003-1423-5970)
- Keriann Schulkers Escalante
- Rob Knight
Institutions
- Scripps Institution of Oceanography (US)
- University of California San Diego (US)
- Rady Children's Hospital-San Diego (US)
- University of Montana (US)
Publication Details
- Journal
- Pediatric Research
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1038/s41390-024-03440-9
- Citations
- 5
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- National Institutes of Health
- University of California, San Diego