Mycobolome of <i>Phialomyces Macrosporus</i> Across OSMAC‐Based Assorted Culture Media
The fungus Phialomyces macrosporus was cultured using the One Strain Many Compounds (OSMAC) strategies to evaluate its metabolome. Variations in the nutrient culture media, culture regime, and cultivation parameters can significantly influence fungal extract quantity and chemical diversity. This study aimed to explore the mycobolome of P. macrosporus in five different culture media and two different cultivation conditions using NMR-based metabolomics. Principal component analysis (PCA) of <sup>1</sup>H-NMR spectra revealed clear differentiation between these samples, highlighting the rice dextrose agar medium (RDA) and potato dextrose broth (PDB) as standard complex media for conducting a fungal metabolite screening program.
Authors
- Elisangela Fabiana Boffo (ORCID: https://orcid.org/0000-0003-2514-1769)
- Regina Geris (ORCID: https://orcid.org/0000-0002-3773-0336)
- Yasmin Almeida Alvarenga (ORCID: https://orcid.org/0009-0006-6765-8458)
- Vitória Evelyn Teles de Jesus (ORCID: https://orcid.org/0009-0009-5176-619X)
Institutions
- Universidade Federal da Bahia (BR)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1002/cbdv.202401547
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado da Bahia