Strontium zinc silicate simultaneously alleviates osteoporosis and sarcopenia in tail-suspended rats via Piezo1-mediated Ca2+ signaling
The current study might provide a universally applicable and efficient strategy to treat musculoskeletal disorders based on bioactive ceramics. The verification of the role of Piezo1-modulated intracellular Ca<sup>2+</sup> during osteogenesis and myogenesis provided a possible therapeutic target against mechanical related diseases.
Authors
- Lingwei Huang (ORCID: https://orcid.org/0000-0002-0653-018X)
- Yiren Jiao
- Yumei Que (ORCID: https://orcid.org/0000-0003-0511-2872)
- Jiang Chang (ORCID: https://orcid.org/0000-0003-1462-6541)
- Chen Yang (ORCID: https://orcid.org/0000-0001-9820-1692)
- Zhen Zeng (ORCID: https://orcid.org/0000-0002-9284-8898)
- Jing Yu (ORCID: https://orcid.org/0000-0003-3119-0890)
- Chen Fan (ORCID: https://orcid.org/0000-0002-6509-6176)
- Huili Li (ORCID: https://orcid.org/0000-0001-7508-1122)
- Chen Wang
- Hangbin Xia
Institutions
- Chinese Academy of Sciences (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Shanghai Institute of Ceramics (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1016/j.jot.2024.07.014
- Citations
- 9
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Wenzhou Medical University
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Shanghai Jiao Tong University
- University of Chinese Academy of Sciences
- School of Medicine, Shanghai Jiao Tong University
- National Key Research and Development Program of China
- Wenzhou Institute of Biomaterials and Engineering