Apolipoprotein E knockout, but not cholesteryl ester transfer protein (CETP)-associated high-density lipoprotein cholesterol (HDL-C) lowering, exacerbates muscle wasting in dysferlin-null mice
CETP/ApoB over-expression in Dysf mice decreases HDL-C without increasing CHOL or exacerbating muscle pathology. High CHOL or nonHDL-C caused by ApoE KO, rather than low HDL-C, likely lead to rodent muscular dystrophy phenotype humanization.
Authors
- Zoe White (ORCID: https://orcid.org/0000-0002-1734-9896)
- Pascal Bernatchez (ORCID: https://orcid.org/0000-0002-3198-1548)
- Marine Théret (ORCID: https://orcid.org/0000-0002-8059-8756)
- Zeren Sun (ORCID: https://orcid.org/0000-0003-1308-5114)
Institutions
- University of British Columbia (CA)
- St. Paul's Hospital (CA)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1186/s12944-024-02227-5
- Citations
- 3
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.98
Funders
- Jain Foundation
- China Scholarship Council
- Canadian Institutes of Health Research