First-Line Nivolumab Plus Relatlimab Versus Nivolumab Plus Ipilimumab in Advanced Melanoma: An Indirect Treatment Comparison Using RELATIVITY-047 and CheckMate 067 Trial Data
Nivolumab plus relatlimab demonstrated similar efficacy to nivolumab plus ipilimumab in the overall population, including most-but not all-subgroups, and improved safety in patients with untreated advanced melanoma. Results should be interpreted with caution.
Authors
- Hussein A. Tawbi (ORCID: https://orcid.org/0000-0003-1942-851X)
- Evan J. Lipson (ORCID: https://orcid.org/0000-0003-2976-0911)
- Laura McDonald (ORCID: https://orcid.org/0000-0002-7087-6548)
- Paolo A. Ascierto (ORCID: https://orcid.org/0000-0002-8322-475X)
- Flavia Ejzykowicz
- Dirk Schadendorf (ORCID: https://orcid.org/0000-0003-3524-7858)
- Andriy Moshyk (ORCID: https://orcid.org/0000-0003-4895-7103)
- Jennell Palaia
- Viviana García-Horton (ORCID: https://orcid.org/0000-0003-0835-800X)
- Anthony Salvatore
- Jean‐Jacques Grob (ORCID: https://orcid.org/0000-0002-0667-153X)
- Georgina Venetia Long (ORCID: https://orcid.org/0000-0001-8894-3545)
- James Larkin (ORCID: https://orcid.org/0000-0001-5569-9523)
- Sarah Keidel (ORCID: https://orcid.org/0000-0002-9489-1451)
- F. Stephen Hodi (ORCID: https://orcid.org/0000-0001-6825-091X)
- Leon A. Sakkal (ORCID: https://orcid.org/0000-0002-8164-6772)
- Yiqiao Xin (ORCID: https://orcid.org/0000-0001-5856-3103)
- Divya Patel (ORCID: https://orcid.org/0000-0003-2659-3695)
- Zheng‐Yi Zhou (ORCID: https://orcid.org/0000-0001-9014-8479)
- Christopher D. Lao
Institutions
- The University of Sydney (AU)
- Royal Marsden NHS Foundation Trust (GB)
- The University of Texas MD Anderson Cancer Center (US)
- Johns Hopkins University (US)
- Aix-Marseille Université (FR)
- University of Michigan (US)
- Bristol-Myers Squibb (United States) (US)
- National Center for Tumor Diseases (DE)
- Dana-Farber Cancer Institute (US)
- Melanoma Institute Australia (AU)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Hôpital de la Timone (FR)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Analysis Group (United States) (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1200/jco.24.01125
- Citations
- 47
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 13.28