Flavonoids as potential therapeutics in male reproductive disorders

Abstract Background Male infertility presents global challenges, as current drug-based treatments demonstrate limited effectiveness due to an incomplete understanding of dysfunctions within the reproductive system. However, there is growing optimism surrounding natural products, particularly flavonoids, which offer promising therapeutic options. Extensive research has unveiled the positive impact of flavonoids on testicular structure, spermatogenesis, and sperm quality. Main body Flavonoids have diverse functions such as immune-stimulating, anti-inflammatory, and antioxidative effects. These properties make them potential inhibitors of male reproductive system problems. This narrative review aims to evaluate the effects of different flavonoids on male reproductive disorders by examining the phytochemical ingredients, traditional applications, potential pharmacological actions, documented effects, and therapeutic applications of flavonoids in functional abnormalities of the male reproductive system. Conclusion This review elaborates on the scientific study findings of flavonoids and recommends their use in male infertility.