Spatial multiomics reveals a subpopulation of fibroblasts associated with cancer stemness in human hepatocellular carcinoma
We identified a CAF subpopulation F5-CAF in liver cancer, which is associated with cancer stemness and unfavorable prognosis. Our results provide potential mechanisms by which the CAF subset in the TME promotes the development of liver cancer by supporting the survival of cancer stem cells.
Authors
- Yufei He
- Hui Dong (ORCID: https://orcid.org/0009-0008-7383-1098)
- Siyu Jing (ORCID: https://orcid.org/0000-0003-2910-4201)
- Yan Xi (ORCID: https://orcid.org/0000-0001-6143-3107)
- Lei Chen (ORCID: https://orcid.org/0000-0002-9380-9559)
- Bin Yi (ORCID: https://orcid.org/0000-0002-9239-8639)
- Dan Liu (ORCID: https://orcid.org/0009-0008-2399-6281)
- Hong Li (ORCID: https://orcid.org/0000-0001-5731-5335)
- Hongyang Wang (ORCID: https://orcid.org/0000-0002-4709-3334)
- Ping Lin
- Xufeng Chen (ORCID: https://orcid.org/0000-0001-9870-4820)
- Na Feng
- Feiling Feng
- He-qi Wang
- Mingxuan Qu
Institutions
- Xuzhou Medical College (CN)
- Second Military Medical University (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Ministry of Education (KR)
- Eastern Hepatobiliary Surgery Hospital (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1186/s13073-024-01367-8
- Citations
- 36
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 10.17
Funders
- National Science Foundation
- National Natural Science Foundation of China
- National Science and Technology Major Project
- Youth Innovation Promotion Association