Reduction in Renal Interstitial Fibrosis in Aged Male Mice by Intestinal Microbiota Rejuvenation
Our findings suggest that the intestinal microbiota regulates the renal microenvironment by reducing immune inflammatory responses through the inhibition of the NF-κB signalling pathway, thereby delaying renal senescence in aged male mice.
Authors
- Wanjun Shen
- Xuefeng Sun (ORCID: https://orcid.org/0000-0003-2984-8905)
- Shaoyuan Cui (ORCID: https://orcid.org/0000-0002-9572-5076)
- Xiangmei Chen (ORCID: https://orcid.org/0000-0003-0302-6866)
- Qi Huang (ORCID: https://orcid.org/0009-0005-1193-7696)
- Tian Li
Institutions
- Capital Medical University (CN)
- Chinese PLA General Hospital (CN)
- Beijing Tian Tan Hospital (CN)
- State Key Laboratory of Kidney Diseases
Publication Details
- Journal
- Gerontology
- Published
- 2024-08-13
- DOI
- https://doi.org/10.1159/000540839
- Citations
- 2
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.93